#synaptic

2026-02-07

Aprendi a usar o Synaptic quando eu usava Ubuntu Gnome. Instalei no Linux Mint Cinnamon porque de vez em quando preciso dele para achar uns pacotes.

#Ubuntu #LinuxMint #Synaptic #Gnome

Buntwerker đŸ€˜ 🎹 â˜źïž â˜ŻïžBuntwerker@norden.social
2026-02-06

Also wenn bei #Debian Updates anstehen, dann aber gleich richtig – 2,6 GB Downloads đŸ˜±

Anschließend will #Synaptic nicht mehr starten (nur ĂŒbers Terminal). Kaputt machen kann nicht nur #Arch 😞

#Linux #Devuan

Fabrizio MusacchioFabMusacchio
2026-02-05

Incorporating structural in () enables dynamic connectivity, reflecting the 's adaptability. By modeling synaptic growth and pruning based on concentration, we can simulate processes such as and . In this post, I reproduce the tutorial on structural plasticity, demonstrating its impact on network stability and :

🌍 fabriziomusacchio.com/blog/202

Sketch illustrating structural plasticity during learning and memory formation. The sketch illustrates the dynamic remodeling of synaptic connectivity through dendritic spine turnover. Left: Under baseline conditions, synaptic networks exhibit continuous formation and elimination of dendritic spines, reflecting ongoing structural plasticity. Middle: During learning or learning related activity, this baseline turnover is transiently increased, leading to enhanced formation and pruning of synaptic contacts. Newly formed spines preferentially emerge near previously activated synapses, promoting the local clustering of synaptic inputs and enabling adaptive rewiring of circuits. Right: A subset of newly formed and activated synapses becomes selectively stabilized, providing a structural substrate for the long term retention of behaviorally relevant connections and memory traces. Source: Bernardinelli, Y., Nikonenko, I., Muller, D., Structural plasticity: mechanisms and contribution to developmental psychiatric disorders, Frontiers in Neuroanatomy, 2014, 8:123, DOI 10.3389/fnana.2014.00123ꜛ (license: CC BY 4.0).Simulation results of the structural plasticity model. The plot shows the temporal evolution of the mean calcium concentration of excitatory and inhibitory neurons (blue and red lines, respectively) and the total number of connections of excitatory and inhibitory neurons (magenta and black dashed lines, respectively). The horizontal lines represent the growth curves for excitatory (blue) and inhibitory (red) neurons. The model demonstrates how the network’s connectivity changes over time based on the calcium concentration in the neurons. The growth curves determine the threshold at which synapses are created or pruned.
Fabrizio MusacchioFabMusacchio
2026-01-12

🧠 New preprint by Zhong et al. proposes a mechanism for in .

Using short-term and synaptic augmentation, their model shows how items can be temporarily suppressed and later retrieved as chunks, increasing effective capacity w/o increasing simultaneous activity.

🌍 doi.org/10.7554/eLife.109538.1

Fig. 1: Illustration of the hierarchical working memory model.
2025-11-17

#Synaptic is a PITA when you want to downgrade a package.
Try from the terminal:

sudo apt install <package name>=<version>

instead.

#linux #tech #ubuntu #debian #packages #conquerthecommandline #shell

Fabrizio Musacchiopixeltracker@sigmoid.social
2025-09-17

🧠 New pre-print by Wiesner et al. (2025) shows non-#synaptic #exocytosis directly from the #axon shaft, regulated by the submembrane periodic skeleton. Using #superresolution #imaging and live assays (#HiLo (VAMP2-pHluorin), #SIM, and correlative two-color #SMLM/ #STORM) they reveal that #axons can release vesicles outside classical #synapses, expanding how we understand #neuronal communication and #AxonalSignaling.

🌍 doi.org/10.1101/2025.09.17.676

#Neuroscience

Figure 1: Spontaneous synaptic and non-synaptic exocytosis along the axon.
Nacktivnacktiv
2025-09-08

Usage of as a software center is a bit akward: first you have to enter the admin password and then it blocks apt because of that. But when I use /sbin/synaptic then it starts without privileges and I can browse packages without entering the admin password, it respects my dark theme and i can use apt install xxx at the same time (of course after entering the admin password). /sbin is not in the PATH variable, therefore synaptic alone ist not sufficient.

Dev Albino :python:v_raton@bolha.us
2025-09-02

#tersoftware de coisas brasileñas kkkkk

Vou trazer um aqui que usei a ins anos atrĂĄs no meu #Debian com XFCE e tenho suspeitas, sem privas concretas que ele foi a base pra o modelo de "App store" por pacotes que conhecemos hoje em dia

O #synaptic do Alfredo Kojima, na época da Conectiva....

Nessa época eu mal existia, mas anos depois tive o help dessa ferramenta e apenas apreciei, o quão complicado deveria ter sido o mundo linux antes dele.

wiki.debian.org/Synaptic

2025-06-13

Conflicting results have been obtained re changes in synaptic strength in the #CerebralCortex during the #Sleep-WakeCycle. This computational study provides a comprehensive understanding & unified framework about #synaptic dynamics during #sleep & wake states @PLOSBiology plos.io/4kHeNwM

A unified framework for synaptic dynamics during the sleep–wake cycle. A Graphical abstract of a unified framework for synaptic dynamics during the sleep–wake cycle. SHY: synaptic homeostasis hypothesis, WISE: wake inhibition sleep excitation.
2025-06-12

Liprin-α & RIM form presynaptic liquid phase-separated condensates #LLPS. This Primer explores a @PLOSBiology study of how these assemblies shape #synaptic fidelity and what their disruption might mean in #neurodevelopmental disease. Paper: plos.io/3Tj5CX7 Primer: plos.io/3HTacJ9

Diagram of how intrinsically disordered proteins and phase-separated condensates coordinate presynaptic active zone structure and function. The presynaptic terminal organizes neurotransmission through dynamic and spatially structured protein assemblies. Synaptic vesicles (SVs) are distributed between a docked pool at the AZ and a reserve pool. Precise coupling between docked SVs and voltage-gated calcium channels enables rapid release, a process supported by an underlying AZ scaffold. Jin and colleagues propose that scaffold components, including Liprin-α and RIM, through their multifaceted intermolecular interaction, assemble into condensates via liquid-liquid phase separation (LLPS) that organize the molecular and functional architecture of the AZ. These dynamic assemblies help cluster SV release machinery while remaining responsive to synaptic activity. Thus, LLPS-driven Liprin-α/RIM condensates not only scaffold presynaptic architecture but also fine-tune vesicle priming and release dynamics. Created with BioRender.com.
2025-06-11

How do scaffolding proteins regulate the assembly of #presynaptic #ActiveZones? This study solves the structure of the liprin-α2/RIM1 complex & shows that it is essential for #synaptic transmission and LLPS-dependent coupling of Ca2+ channels & synaptic vesicles @PLOSBiology plos.io/3Tj5CX7

Top left: Crystal structure of the liprin-α2_CC2N/RIM1_C2B complex. Two neighboring CC2N coiled coils (colored green and gray, respectively), with four bound C2B molecules (colored magenta), are shown. Right inset: Molecular details of interface I formed between the N-terminal part of CC2N and C2B. Salt bridges and hydrogen bonds are indicated by dashed lines. Bottom inset: Molecular details of interface II formed between the C-terminal part of CC2N and C2B. The interconnectivity between interfaces I and II in the complex of one C2B molecule and two CC2N coiled coils is displayed. Salt bridges and hydrogen bonds are indicated by dashed lines. Top right: Surface representation of C2B and CC2N, showing the spatial relationship between the PIP2-binding site and bound CC2N. Key negatively charged residues on the CC2N structure are highlighted in red. Bottom right: Confocal imaging analysis of the LLPS mixture containing the ELKS1/liprin-α2_CC12 (WT or R346E) condensate and the RIM1/RBP2_(SH3)3 condensate. Magnified views of representative RIM1 (a) and ELKS1 (b) droplets were displayed below, with line analyses of fluorescence signal intensities along the indicated lines.
Open Titus :opensource: :tux:opentitus@mastodon.uno
2025-05-16

🇼đŸ‡č🐧Ufficio Zero Linux Lorena - Guida alla configurazione iniziale

youtu.be/9xMbbbzlRc4

Come da vostra richiesta, ecco un video dove parliamo meglio di questa distribuzione MADE in ITALY basata su PCLinuxOS.
Buona visione

@ufficiozero @ufficiozero@pixelfed.uno @ufficiozerolinuxos #windows #opensourceitalia #ufficiozerolinux #gnulinux #pclinuxos #rpm #synaptic

ehtron :verify:đŸ–„ïžâ€‹â€‹đŸšČ:signal:ehtron@mastodon.de
2025-03-15

Hi 😀​ da in #linuxmint #22.1 (#xia) #synaptic unverstĂ€ndlicher weise, nicht mehr dabei ist, habe ich mich des themas mal angenommen 😀​
ehlertronic.de/linux/tipps-tri

2025-02-25

Some days with Debian Sid it's a mistake to go 'apt upgrade'. This is one of those days. Either the apt xapian indexer has stopped working (it reports success), or synaptic has stopped using it (it logs nothing adverse), because the filter box that made synaptic usable has vanished.

#debian #xapian #apt #synaptic

AprovechĂ© un gran descuento en el Ășltimo #cybermonday2024,algo asĂ­, y me comprĂ© un pack de cursos en la @linuxfoundation y ahora mismo estoy cursando "Linux for Cloud Technicians Essentials LFS203"...

Y en el apartado de "Package Management", en #synaptic, dice lo siguiente:
" #ubuntu no longer installs synaptic by default, as it prefers use of the Ubuntu Software Center for marketing reasons. Thus, the first thing you should do is install synaptic on your system."

😆😆 ..."the first thing"...👌

2025-02-02

Synaptic – Enter the Void Review

By Dolphin Whisperer

Nothing marks the passage of time like an album released decades after the core of its sound kicking your brain back to its youth. Now, my birth wasn’t so long ago that I’d consider myself decrepit. But when a band like Synaptic walks The Thin Line Between melodic, technical, and just a touch progressive death metal sound from a pre-Relentless Mutation—hell a pre-Incurso, even—world, I step right back into a mindset of no sweep too repetitive, no riff to crunchy or jagged, and thrashin’ about concerts carefree with no ear protection.1 The fretboard gymnastics across Enter the Void do, after all, possess a youthfulness in the sense that fingers tarnished by the plights of time-based decay could not fathom the nimble taps and extended arpeggiations that adorn its svelte run. Nostalgia alone can’t be the only draw, though.

Having roots in Germany as far back as 2004 under the name Preemptyve Strike, Synaptic’s surviving creative force, guitarist Simon Herbert, has likely lived many of the historical landmarks that adorn the memories of extreme death metal connoisseurs across the past twenty years. As such, a harmonic focus steered by technical riffage and virtuosic bass pops2 breathes the language of the melodically inclined aggression—undervalued acts of olde like Neuraxis or early Arsis. With this kind of construction, the hooks lie just as much in the twisted play of Gothenburg-weight flexing (“The Lost Continent,” “Memories of a Forgotten Future”) as they do in the hypnosis of tapped and layered sonic excess (“Malfunctional Minds,” “City of Glass”). Little new exists in the scale exercises that build tension and escalate song narratives here. Nevertheless, Synaptic finds an entertaining home in their well-carved path.

Though not the most dynamic display of tech death—the compression necessary for these distorted tones to run truer to note against each other makes accomplishing that task difficult, typically—Synaptic defies the tradition of crispy rhythm tones and crack-a-lack drum splatters to wear their chosen style like broken-in denim. In particular den Hertog wears his thick-stringed chatter in frequencies that stray away from competition with treble-loaded taps and blackened tremolo assaults (“Malfunctional Minds” especially), all while stepping with a fretted presence that clangs distinct from a double-kick pummel. Young engineer Ben Jones (also engineer for last year’s Feind album) has reigned in well the diversity of guitar voices that Herbert has chosen allow half-time bridges (“The Lost Continent,” “Architects of the Night”) and long-form excursions (“City of Glass”) to land with high punch and low fatigue. Despite the kitwork being completely at the hands of programming (also Herbert), Jones has integrated its flow well such that it took me exploring the credits to realize the absence of sticks behind the percussion.

Between the extensive and studied scale mastery, progressive breaks into group choruses and verses, and harsh vocal palettes that stay within the genre confines, Synaptic struggles to build a face of their own. It’s a tough gig to carve a niche in this extreme metal world with bands like Archspire driving for harder and harder-to-reach tempos, or others like First Fragment throwing every sticky arpeggio and guitar (and bass) solo imaginable at the wall. Enter the Void subsists on smart composition first, which means that its fugal prowess must hit with a crescendo of excess or hook so mighty it can’t be denied. As it stands, though Herbert’s peaks in solo-land find a more smooth, buttery path to the top. And with three of the eight tracks serving either an introductory of transitory passage (the closer might as well be part of “City of Glass” too), Synaptic spends an unfortunate amount of its rather short run here building an atmosphere whose brightest moments ride low magnitude waves.

As countless other bands have chased this same technical death metal high, Enter the Void too doesn’t enter the scene with any major shake or rattle. Given the level of affection for the style in exposition and careful refinement along the genre playbook, though, it doesn’t seem much like Synaptic aimed to reinvent anything. Of course, a novel approach isn’t necessary to give fans of certain sounds a good time. In Enter the Void, those searching for a snappy, atmospheric play on death metal riffy and sweeping will find plenty of reward.

Rating: 3.0/5.0
DR: 7 | Format Reviewed: PCM3
Label: Self Release
Websites: synapticmetal.bandcamp.com | instagram.com/synaptic.techdeath
Releases Worldwide: January 15th, 2025

#2025 #30 #Arsis #DeathMetal #EnterTheVoid #GermanMetal #LifelessChasmRecords #Neuraxis #ProgressiveDeathMetal #Review #Reviews #SpawnOfPossession #Synaptic #TechnicalDeathMetal

2025-01-17

"SYNAPTIC CURRENTS". Abstract digital painting by A.G. (c) 2025. All Rights Reserved.

CrĂłnicas de un Linuxerocronicasdeunlinuxero@open.audio
2024-12-27

Episodio 43: ¿Por qué usar Debian o derivadas? (para usuarios novatos).

#archlinux #Debian #fedora #flatpak #FreeSoftware #GNULinux #kdeneon #linuxmint #Mastodon #peppermint #popos #sparkylinux #synaptic #ubuntu #voidlinux

open.audio/library/tracks/4300

2024-12-09

A computational modeling approach reveals how local changes in potassium concentration regulate dendritic integration of #synaptic inputs, revealing that 'potassium hotspots’ act as a gain control mechanism #PLOSBiology plos.io/49rlAWo

2024-05-26

lxpolkit is one program which will allow you to run something which requires polkit. (such as #synaptic) Necessary for window managers / compositors which don't use a desktop environment, such as sway.

For synaptic using X Windows, you will also need to give root access to your server. Do this with xhost.

xhost SI:localuser:root

should do the trick. You may need this on Wayland as well, as synaptic interfaces with X.

#debian #linux #polkit

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