The latest collection of commentary and Essays in @PLOSBiology is devoted to #immunometabolism.

We highlight how the interplay between systemic metabolism and the immune response impact tissue and organismal functions, as well as the therapeutic potential of manipulating immunometabolism.

⚛️ Nicole Chapman and Hongbo Chi advocate for the use of systems biology approaches as discovery tools for new therapeutic targets

💉 Yun Sok Lee investigates the process of metaflammation, the chronic low-grade inflammatory response that occurs in metabolic diseases such as obesity and type 2 diabetes, exploring how systemic changes in metabolism can affect tissue-resident immune cells

🦠 Griffin Gowdy and Alice Prince look at the role of immunometabolites in both driving and combating bacterial infections, with a focus on lung pathogens

🥗 On a more holistic level, Guang Sheng Ling and colleagues suggest a two-pronged approach to target immunometabolism through pharmaceutical and lifestyle interventions, with a focus on cancer

The collection was edited by Claudio Mauro, Lucas Smith and Joanna Clarke

#immunology #metabolism #cancer #aging #inflammation #infection

https://collections.plos.org/collection/facets-of-immunometabolism/

The article describes a study linking depressive symptoms and anxiety with stronger inflammatory responses among sexual minority adults compared with heterosexuals, as indicated by higher IL-6 and CRP levels. The association remains after adjusting for age, race, sex assigned at birth, education, and health conditions, and is partly explained by more adverse childhood experiences in the sexual minority group. The authors suggest that chronic stress related to minority status may sensitize the immune system, contributing to higher inflammation when distress is present.

This piece highlights how social stressors can translate into measurable biological processes, illustrating biopsychosocial pathways in mental and physical health. It is of particular interest to those studying psychology for its integration of minority stress theory with inflammatory biology and health disparities.

Article Title: Depression and anxiety linked to stronger inflammation in sexual minority adults compared to heterosexuals

Link to PsyPost Article: ift dot tt/SGd10NX

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#MentalHealth #Inflammation #SexualMinority #MinorityStress #HealthDisparities

A really clear, thoughtful piece on obesogens — I found this genuinely worth reading and wanted to share it.

https://goodjuju.thegoodinside.com/toxins-obesogens

#phthalates #wellness #health #diet #inflammation #healthyliving

Replicated mouse studies have found that blocking inflammation after surgery prolongs pain and the recovery period.

Summary: https://www.futurity.org/inflammation-after-surgery-pain-recovery-3320972/

Original paper: https://www.dovepress.com/unexpected-role-of-tnf-signaling-in-the-resolution-of-postoperative-pa-peer-reviewed-fulltext-article-JPR

Embrace the pain, I guess.

#Science #Surgery #Pain #Inflammation

NOS2 and PTGS2 Genes’ Expression during Oxidative Stress in the Blood of Patients with Osteoarthritis after SARS-CoV-2 Infection - #SARSCoV2 #osteoarthritis #inflammation #oxidativestress #NOS2 #PTGS2 #geneexpression - https://link.springer.com/article/10.3103/S0095452725060039

Patterns of #inflammation and altered protein levels predictive of Type 1 #Diabetes (T1D) are detectable at birth, indicating that the disease process may initiate during fetal development rather than commencing solely with the appearance of #autoantibodies later in childhood
#Immunology #Proteomics #sflorg
https://www.sflorg.com/2026/01/imgy01282601.html

Chronic low-grade metabolic #inflammation drives insulin resistance and metabolic dysfunction in #obesity. In this #PLOSBiology Essay, Yun Sok Lee highlights the lesser known beneficial effects of this inflammation and how they can transition into detrimental outcomes. https://plos.io/4sOCOqh

🥂 Our paper on platelet-derived integrin- and tetraspanin-enriched tethers (PITTs) is now out in Science 🧬🩸

🔬 Non-activated #platelets shed αIIbβ3-rich tethers that amplify #inflammation while impairing platelet function.

🥳 Huge thanks to all co-authors for an amazing team effort. 🙏

🔗 https://doi.org/10.1126/science.adu2825

#Platelets #Inflammation #ThromboInflammation

Loss of cPLA2α function attenuates #inflammation and epithelial thickening in a mouse model of Haemophilus influenzae-mediated #COPD exacerbation

https://www.sciencedirect.com/science/article/pii/S2666517426000118 #OpenAccess #lungs #microbiology

Loss-of-function mutations in PLD4 linked to SLE:

🔬 PLD4 mutations led to high TLR7/9 activation
🔬 5 patients showed reduced exonuclease activity
🔬 Effective baricitinib treatment in mice

#SLE #Genetics #Inflammation #Pub2Post
https://tnyp.me/vwTf6xf5/m

A study in Nature shows that M101—an oxygen carrier from the marine worm *Arenicola marina*—significantly reduces inflammation and tissue destruction caused by *P. gingivalis*. A promising step for periodontal therapy! 🧫🌊🦷

Read more: https://www.nature.com/articles/s41598-020-71593-8
#Periodontitis #Inflammation #BiomedicalResearch #ScienceNews

Systems modelling explains: A #cybernetic theory of the molecular processes in #COVID-19 predicts oscillatory #inflammation and virus load in severe forms, which result from increased #TMPRSS2 expression.

#Dubai #chewy cookie #craze raises #health concerns, experts warn
"such foods can blunt signalling for leptin, responsible for satiety, increas'g likelihood of #overeating.. Refined sugars r absorbed rapidly, sharply rais'g blood glucose, while te high fat content slows digestion & prolongs tt elevated state. “Tis puts sustained pressure on te pancreas to produce insulin & makes te blood more viscous, interfer'g w circulation” Prof Lee.. can promote chronic #inflammation"
https://www.straitstimes.com/asia/east-asia/dubai-chewy-cookie-craze-raises-health-concerns-experts-warn

Two takeaways for mental health professionals: First, early father–child warmth and engagement are associated with calmer coparenting at age two, and this state predicts lower inflammation (CRP) and better HbA1c in children around age seven. Second, the study found this link for fathers but not for mothers, suggesting paternal behavior can uniquely influence family dynamics and child health outcomes.

Article Title: Early father-child bonding predicts lower inflammation in children

Link to PsyPost Article: ift dot tt/8qmWVkE

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#FamilySystems #FatherInvolvement #Coparenting #Inflammation #ChildHealth

Cortisol, Inflammation, SIRT1 in Depression?

Is NAD+ the remedy?

New study indicates that a decrease in nerve cell cholesterol caused by cortisol, inflammation & low SIRT1 activity may be a cause of major depression.

So, do statins exacerbate depression?

And since SIRT1 is NAD⁺-dependent, could NAD⁺ boosters treat or prevent depression?

https://threadreaderapp.com/thread/2011496092387721557.html
#Cortisol #Inflammation #SIRT1 #Depression #NAD

Thinking about getting a tattoo? 🖼️
Your immune system wants a vote. 🗳️
Tattoo regret isn’t just aesthetic. 😔
Science suggests it may be biological. 🔬
https://talesofmanythings.com/blog/?p=573
#Tattoo #Ink #ImmuneSystem #Inflammation #Science #BodyArt #BiologicalMinimalism

#Cholesterol #HeartDisease #Statins #LDLCholesterol #Inflammation #CardiovascularHealth #HealthFacts #MedicalScience #biohacking #biohacker #biohackingsecrets #biohackers #biohacks #biohackinglife #ScientificDebate #HealthDiscussion https://mastodon.social/@biohackingpathway/115875218604642979

#CrohnsDisease #GutHealth #ImmuneSystem #Inflammation #AutoimmuneConditions #HealthyLiving #IBS #MedicalExploration #NutritionEducation #biohack #biohacking #biohacker #biohackingsecrets #biohackers #PathogenDefense https://mastodon.social/@biohackingpathway/115869578792915000

Which of the following conditions can cause inflammation and pain in the hand joints?
A) Hepatitis
B) Rheumatoid arthritis
C) Pneumonia
D) Diabetes insipidus
#inflammation #jointpain #arthritis #joint ... Continue to: https://www.facebook.com/1130092409221646/posts/1224083769822509

When #inflammation in the body goes unchecked, it can cause #fibrosis, or tissue scarring that may lead to organ dysfunction or even failure. This can happen in conditions such as inflammatory bowel diseases (ulcerative colitis and Crohn’s disease), chronic viral infections, interstitial lung fibrosis, chronic autoimmune skin diseases such as scleroderma, and scars associated with heart disease.
#MolecularBiology #Medical #sflorg
https://www.sflorg.com/2026/01/mbio01072601.html