Lmst

#fibrosis

Lipid #nanoparticles successfully delivered a full-length, healthy #CFTR gene into human airway cells, restoring essential biological function in a cystic #fibrosis model without the use of viral vectors.
#Medical #Nanotechnology #Nanomedicine #GeneTherapy #PulmonaryMedicine #sflorg
https://www.sflorg.com/2026/02/med02172601.html

Inhibition of the epigenetic co-activators p300/CBP prevents alveolar type 2 (AT2) cells from becoming trapped in a pathogenic "alveolar transitional cell state" (ATCS), thereby blocking the progression of idiopathic #pulmonary #fibrosis (#IPF ).
#RegenerativeMedicine #Epigenetics #Genetics #Medical #sflorg
https://www.sflorg.com/2026/02/gen02142601.html

Hola Titánicos, hoy os explico que es a aracnoiditis, un trastorno que implica inflamación y daño de la aracnoide, una de las capas que componen las meninges que cubren el cerebro y la médula espinal, es decir, el sistema nervioso central.

https://somosdisca.es/que-es-la-aracnoiditis/

#aracnoiditis #aracnoiditisadhesiva #dolorneuropatico #dolor #dolorcronico #salud #enferrmedad #sistemanerviosocentral #infecciones #traumatismos #incontimencia #lesionmedular #fibrosis #enfermedadincapacitante #salud #enfermedad #saludmental #dependencia #Disability #disabilities #visibilidad #discapacidad #DiscapacidadAuditiva #visibilizandoladiscapacidad #enfermedadesraras #enferemdadrara #discapacidad #cuidados #vertigo #mareos #titanicos #titan #gentetitanica #somosdisca #somostitánicos

When #inflammation in the body goes unchecked, it can cause #fibrosis, or tissue scarring that may lead to organ dysfunction or even failure. This can happen in conditions such as inflammatory bowel diseases (ulcerative colitis and Crohn’s disease), chronic viral infections, interstitial lung fibrosis, chronic autoimmune skin diseases such as scleroderma, and scars associated with heart disease.
#MolecularBiology #Medical #sflorg
https://www.sflorg.com/2026/01/mbio01072601.html

Hola Titánicos, cada 8 de septiembre se celebra el día Mundial de la Fibrosis Quística, para visibilizar a esta enfermedad rara que afecta a 72.000 personas en el mundo

https://somosdisca.es/dia-mundial-de-la-fibrosis-quistica-2025/

#díaMundialdelaFibrosisQuística #FibrosisQuistica #FibrosisPulmonar #fibrosis #enfermedadrespiratoria #enfermedadpulmonar #salud #enfermedad #enferemdadrara #visibilidad #prevencion #saludmental #cuidados #cuidador #calidaddevida #DiscapacidadNoEsIncapacidad #incapacidadyjubilacion #incapacidad #disca #disability #disabilities #titan #titanicos #itanico #gentetitanica #somosdisca

🧬 This Taiwanese biotech startup is taking on one of medicine’s toughest challenges: fibrosis.

With a groundbreaking nucleic acid therapy aimed at reversing lung scarring in diseases like IPF, they’re not just slowing damage — they’re targeting the root cause.

🔬 Read how this team could change the future of pulmonary care:

👉 https://www.sparknify.com/post/this-taiwanese-biotech-startup-is-taking-aim-at-fibrosis-with-a-groundbreaking-nucleic-acid-therapy

#Biotech #Fibrosis #IPF #RNAtherapy #TaiwanStartups #Healthtech #Sparknify

Hola Tániticos, hoy os hablaré de lo qué es el Síndrome de la espalda fallida, en que consiste, sus síntomas, causas y como disminuye la calidad de vida de quien lo padece.

¿Después de una operación de columna persiste el dolor, incluso a aumentado? Quédate porque puede que esta información te interese.

https://somosdisca.es/que-es-el-sindrome-de-la-espalda-fallida/

#Síndromedelaespaldafallida #espaldafallida #españda #herniadedisco #herniadiscal #operaciondeespalda #operaciondecolumna #ProblemasDeColumna #radiculopatia #dolorcronico #dolor #unidaddedolor #cirugia #CirugiaFallida #fibrosis #CompresionNerviosa #hernia #DegeneracionDiscal #MovilidadRedicida ##SaludMental #Depresion #Ansiedad #Opiaceos #EstenosisForaminal #Estenosis #DolorRAdicular #InestabilidadLumbar #DolorLumbar #Lumbalgia #descompresiónMedular #EstenosisRadicular #infección #CalidadDeVida #MenosCalidadDeVida #Fisioterapia #Radiofrecuencia #Incontinencia #salud #enfermedad #discapacidad #disabilities #disability #Titan #Titanico#Titanicos #YosoyTitanico #GenteTitanica #Somosdisca

New insights into alcohol-related liver disease: in the recent preprint, we mapped niche-specific cell interactions at ultra-high resolution (2μm spots), described hepatic niche markers, and cell subtypes defined by them. Stay tuned!
#ALD #SpatialBiology #Fibrosis 🧪

https://www.biorxiv.org/content/10.1101/2025.03.15.643421v1.full.pdf+html

Hola Titánicos, cada 8 de septiembre se celebra el día Mundial de la Fibrosis Quística, para visibilizar a esta enfermedad rara que afecta a 72.000 personas en el mundo.

https://somosdisca.es/dia-mundial-de-la-fibrosis-quistica-2024/

#FibrosisQuistica #FibrosisPulmonar #fibrosis #enfermedadrespiratoria #nfermedadpulmonar #salud #enfermedad #enferemdadrara #visibilidad #prevencion #cuidados #discapacidad #disca #disability #disabilities #titan #titanicos #itanico #gentetitanica #somosdisca

🔬🦴🩻🧪 Multifaceted bone response to immunomodulatory magnesium implants: Osteopromotion at the interface and adipogenesis in the bone marrow 🔍

https://doi.org/10.1016/j.biomaterials.2024.122779

#biomaterials #tissueengineering #regenerativemedicine #biology #implants #inflammation #immunomodulation #fibrosis #medicine #healthcare #engineering #magnesium #science

$Orthopedic implants made of biodegradable magnesium (Mg) provide an alternative to nondegradable implants for fracture repair. Widely reported to be pro-osteogenic, Mg implants are also believed to be anti-inflammatory and anti-osteoclastic, but this is difficult to reconcile with the early clinical inflammation observed around these implants. Here, by surveying implant healing in a rat bone model, we determined the cellular responses and structural assembly of bone correlated with the surface changes of Mg implants inherent in degradation. We show that, compared to titanium, both high-purity (99.998%) and clinical-grade, rare earth-alloyed (MgYREZr) Mg implants create an initial, transient proinflammatory environment that facilitates inducible nitric oxide synthase-mediated macrophage polarization, osteoclastogenesis, and neoangiogenesis programs. While this immunomodulation subsequently reinforces reparative osteogenesis at the surface of both Mg implants, the faster degradation of high-purity Mg implants, but not MgYREZr implants, elicits a compositional alteration in the interfacial bone and a previously unknown proadipogenic response with persistent low-grade inflammation in the surrounding bone marrow. Beyond the need for rigorous tailoring of Mg implants, these data highlight the need to closely monitor osseointegration not only at the immediate implant surface but also in the peri-implant bone and adjacent bone marrow.$

🔬🦴🧪 Magnesium implant degradation provides immunomodulatory and proangiogenic effects and attenuates peri-implant fibrosis in soft tissues" 🔎

https://doi.org/10.1016/j.bioactmat.2023.02.014

#biomaterials #tissueengineering #regenerativemedicine #biology #implants #inflammation #immunomodulation #fibrosis #medicine #healthcare #engineering #magnesium #science

Implants made of magnesium (Mg) are increasingly employed in patients to achieve osteosynthesis while degrading in situ. Since Mg implants and Mg2+ have been suggested to possess anti-inflammatory properties, the clinically observed soft tissue inflammation around Mg implants is enigmatic. Here, using a rat soft tissue model and a 1–28 d observation period, we determined the temporo-spatial cell distribution and behavior in relation to sequential changes of pure Mg implant surface properties and Mg2+ release. Compared to nondegradable titanium (Ti) implants, Mg degradation exacerbated initial inflammation. Release of Mg degradation products at the tissue-implant interface, culminating at 3 d, actively initiated chemotaxis and upregulated mRNA and protein immunomodulatory markers, particularly inducible nitric oxide synthase and toll-like receptor-4 up to 6 d, yet without a cytotoxic effect. Increased vascularization was demonstrated morphologically, preceded by high expression of vascular endothelial growth factor. The transition to appropriate tissue repair coincided with implant surface enrichment of Ca and P and reduced peri-implant Mg2+ concentration. Mg implants revealed a thinner fibrous encapsulation compared with Ti. The detailed understanding of the relationship between Mg material properties and the spatial and time-resolved cellular processes provides a basis for the interpretation of clinical observations and future tailoring of Mg implants.

@inkican

"The drug, a manufactured antibody that attacks interleukin-11, is being trialled in patients with lung fibrosis. This is where the lungs become scarred, making it harder to breathe."

Hope the trial is successful.

#fibrosis #PulmonaryFibrosis #lungs #IL11

@ScienceScholar

Really exciting. I wish I could access the research article.

I wonder if the anti-fibrotic alkaloids are dopamine agonists.*

* https://doi.org/10.1126/scitranslmed.aau6296

#NaturalProducts #fibrosis

Improved #pulmonary #function and #exercise #tolerance despite persistent pulmonary #fibrosis over 1 year after severe #COVID19 infection http://thorax.bmj.com/cgi/content/short/79/5/472?rss=1

Despite a high prevalence of fibrotic patterns (64%), pulmonary function, #grip strength, 6 min #walk distance and frailty normalised. Overall, #dyspnoea, #cough and #exhaustion did not improve and were not correlated with pulmonary function or radiographic fibrosis at 15 months, suggesting non-respiratory aetiologies.

#Cystic #fibrosis is a #genetic disease that causes serious and sometimes fatal #respiratory and #digestive disorders. A new treatment, available since 2020, improves lung function and quality of life. However, it does not always eradicate the #bacteria responsible for respiratory infections.
#Biomolecular #Genetics #CF #sflorg
https://www.sflorg.com/2024/04/bmol04042402.html

#Cystic #fibrosis is the most common, life-limiting genetic condition in Australia. It affects the #lungs, #digestive system, and reproductive system, producing excess mucus, infections, and blockages.
#Pharmaceutical #Nanotechnology #Medical #sflorg
https://www.sflorg.com/2024/03/phar03292401.html

Improved #pulmonary #function and #exercise #tolerance despite persistent pulmonary #fibrosis over 1 year after severe #COVID19 infection http://thorax.bmj.com/cgi/content/short/thorax-2023-220370v1?rss=1

Overall, dyspnoea, cough and exhaustion did not improve and were not correlated with pulmonary function or radiographic fibrosis at 15 months, suggesting non-respiratory aetiologies.

Firsts are worth celebrating. In this case, the cause for celebration is especially great. Late this week, @us_fda approved #resmetirom to be the first ever treatment for #MASH with #fibrosis.
This brings the promise of much progress to come.
https://conscienhealth.org/2024/03/fda-approves-resmetirom-first-ever-for-mash-with-fibrosis/

PhD position in ERC funded project on myeloproliferative neoplasms

RWTH Aachen

Come and join us as a #PhD student to dissect molecular and cellular mechanisms in bone marrow #fibrosis in #MPN in an ERC funded research project.

See the full job description on jobRxiv: https://jobrxiv.org/job/rwth-aachen-27778-phd-position-in-erc-funded-project-on-myeloproliferative-ne...
https://jobrxiv.org/job/rwth-aachen-27778-phd-position-in-erc-funded-project-on-myeloproliferative-neoplasms/?feed_id=72666

PhD position in ERC funded project on myeloproliferative neoplasms

RWTH Aachen

Come and join us as a #PhD student to dissect molecular and cellular mechanisms in bone marrow #fibrosis in #MPN in an ERC funded research project.

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