Lmst

#SIRT1

Cortisol, Inflammation, SIRT1 in Depression?

Is NAD+ the remedy?

New study indicates that a decrease in nerve cell cholesterol caused by cortisol, inflammation & low SIRT1 activity may be a cause of major depression.

So, do statins exacerbate depression?

And since SIRT1 is NAD⁺-dependent, could NAD⁺ boosters treat or prevent depression?

https://threadreaderapp.com/thread/2011496092387721557.html
#Cortisol #Inflammation #SIRT1 #Depression #NAD

Text Shot: SIRT1 loss alters expression of cholesterol synthesis & transport, reducing membrane cholesterol and impairing synaptic function. This links metabolism, epigenetics, and mood
Lowering cholesterol in healthy neurons reproduced depression-like defects. Conversely, restoring cholesterol rescued synapses and glutamate responses across all models
This study raises a testable idea: could NAD⁺ precursors (NR, NMN, etc.) help restore SIRT1 activity, normalize neuronal cholesterol, and improve synaptic function in subsets of major depressive disorder?

🌗 高劑量NMN通過NAM介導的SIRT1-AMPK-ACC途徑促進鐵死亡以抑制肺腺癌生長 - PMC
➤ NMN可抑制肺腺癌生長，通過NAM介導的SIRT1-AMPK-ACC途徑促進鐵死亡。
✤ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177531/
本研究發現高劑量NMN可通過NAM介導的SIRT1-AMPK-ACC途徑促進鐵死亡以抑制肺腺癌生長，並提供了一種新的治療肺腺癌的觀點。
+ 這項研究為肺腺癌的治療提供了新的思路，值得進一步研究。
+ 高劑量NMN的應用前景非常廣闊，未來可能有更多的應用價值。
#肺腺癌 #NMN #鐵死亡 #SIRT1-AMPK-ACC途徑