The cover of February's issue of Genome Biology and Evolution features the work of Kosakyan et al. on the evolution of mitochondrial genomes in the Gastrotricha.
#mtDNA
Good discussion here of the peopling of #Sahul by a 'long chronology', that is reaching New Guinea and Australia by 60,000 years.
Previous data showing Aus and PNG populations carry the signature of Neanderthal interbreeding (some 55-50 Kya in the Middle East) suggests the 'chronology' was more recent OR all the first wave left no descendants today. But these calibrated #mtDNA results suggest different, people do descend from the early pioneers, entering via two routes, the main one N Indonesia-Philippines, and another southerly one.
#archaeogenetics #maritimearchaeology
https://phys.org/news/2025-12-guineans-aboriginal-australians-descend-groups.html
🎄 Türchen 12: Mitochondriale DNA
Ein Kind mit drei Eltern? Möglich dank mitochondrialer DNA – winzige Kraftwerke mit eigenem Genom. Prof. Dr. Julia Schulze-Hentrich erzählt.
🎧 https://abc-der-genetik.podigee.io/16-mitochondriale-dna
#ABCderGenetik #mtDNA #Genetik
“Our finding multiple high‐level and sub‐haplogroup contexts of causal mtDNA pathogenic variants in PMD patients proves that although a possible contributor, the modifying effects of haplogroup context are not a main driver of the diagnostic disparities evident for African patients.” #DNA #Haplogroup #HaplogroupL #isogg #mitochrondria #PMD #mtDNA https://pmc.ncbi.nlm.nih.gov/articles/PMC12254466/
Aufgrund statistischer Analysen der mitochondrialen #DNA (#mtDNA) des Homo sapiens wird angenommen, "dass es vor rund 70.000 bis 80.000 Jahren einen genetischen Flaschenhals beim Menschen gegeben haben könnte; seinerzeit hätten demnach nur etwa 1.000 bis 10.000 Individuen von Homo sapiens, größtenteils in Afrika, gelebt."
😳
Den heutigen prozentualen Anteil an Vollidioten vorausgesetzt, konnte sich der " okay-e" Teil der Menschheit zu dieser Zeit in einer Hütte treffen...
#HomoSapiens
Nucleic Acids Research used ChatGPT (credited) to generate the cover image for their latest issue. This is one of my favorite journals, but this is a really shitty thing to do. They take in tons of money by charging authors article processing fees, so they can afford to hire an artist. #Science #ScienceMastodon #AcademicChatter #Bioinformatics #DNA #mtDNA
A new study links the Harbin cranium to Denisovans using DNA hidden in dental calculus. 🦷🧬 The mtDNA connects to Siberian lineages and suggests Denisovans spread widely across Pleistocene Asia. #MetagenomicsMonday #SPAAM #aDNA #Denisovan #archaic #mtDNA #calculus
https://doi.org/10.1016/j.cell.2025.05.040
#Neanderthals deep into #Asia. New #mtDNA from Crimea, Starosele
https://www.sciencenews.org/article/dna-neandertals-traveled-asia
Liu, Liu & Hu retrieved 2,102 mtDNA sequences of 80 Carnivora species from public databases, uncovering several hidden issues that may compromise evolutionary and genetic inferences.
🧬 Is a “common deletion” in mitochondrial DNA the hidden link between energy metabolism and cancer?
🔗 Mitochondrial DNA common deletion in cancer: Emerging evidence and methodological challenges. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.010
📚 CSBJ: https://www.csbj.org/
#Mitochondria #CancerResearch #Genomics #Oncology #Biomarkers #MolecularBiology #mtDNA #PrecisionMedicine #CancerBiology #MedicalResearch
🥂 🐌 First paper out from our Cuba-UK collaboration 🐌🥂. We used mtDNA and rRNA sequences to place beautiful Polymita snails in a phylogeny. Basically, they are basal to a whole bunch of other important and diverse snail groups. https://academic.oup.com/mollus/article/91/2/eyaf006/8173425
There's an obvious #paperthemetune, the "Polymita song", by collaborator Norvis Hernandez and others. https://youtu.be/1srl4_JI_Fs?si=G3Z5bVLCDWR554nl #snails #mtDNA #phylogenetics #UoN
new paper: "Genetic and reproductive strategies to prevent mitochondrial diseases" https://doi.org/10.1093/humupd/dmaf004
"Mitochondrial DNA (mtDNA) diseases pose unique challenges for genetic counselling and require tailored approaches to address recurrence risks and reproductive options. The intricate dynamics of mtDNA segregation and heteroplasmy shift significantly impact the chances of having affected children."
This is very exciting news for #mtDNA
Fiona's next chapter/paper saw her sampling Pocillopora spp. and associated symbiont communities along a tropical-temperate gradient, and finding that subtropical communities are genetically distinct from their tropical counterparts
https://link.springer.com/article/10.1007/s00338-024-02601-w
#CoralReefs #Japan #mtDNA #coral
“Variation of the mitochondrial genome has been also studied as possible source of incomplete penetrance. In fact, constitutive variants defining mtDNA haplogroup J have been found to increase penetrance in families with the m.11778G>A and, more consistently, with the m.14484T>C mutations.” #dna #isogg #mtdna #mitochondrial #haplogroupj
Mitochondria as you’ve never seen them
https://www.nature.com/immersive/d41586-025-00269-y/index.html
https://news.ycombinator.com/item?id=42899168
Comments
me: former mitochondrial (mt) researcher, published
mt difficult to prepare/isolate intact/pure
extraordinary imagery shows why
Yet another "illustration" 😉 of crit imp. of fundamental research
https://www.niehs.nih.gov/research/atniehs/labs/gisbl/pi/mdnar
https://tools.niehs.nih.gov/polg/ --> mt. diseases ...
https://en.wikipedia.org/wiki/Mitochondrial_disease
#BasicScience #mitochondria #CellBiology #PolG #disease #BasicResearch #MolecularGenetics #PEO #mtDNA #NIEHS
“These findings suggest that elevated Functional Impact (FI) score of mtDNA variants might contribute to premature aging in young adulthood.” #isogg #dna #epigenetics #mtDNA #mitochondrial #biologicalclock
SciTech Chronicles. . . . . . . . . . . . . . . . . . . . .Jan 24, 2025
#Buses #autonomous #Imagry #Level-4 #self-generated #map #mitochondria #lymphocytes #immunotherapy #mtDNA #senescence #open-source #Cost #Security #Documentation #Customizability #Sustainability #LLM #Clone #Fudan #Meta #Alibaba #Frontier #AI #Bees #Hive #AprilTags #Pollen #foraging
Well interesting, #matrilocality of the Durotriges people:
'In southern Britain, the Late Iron Age Durotriges tribe often buried women with substantial grave goods. Here we analyse 57 ancient genomes from Durotrigian burial sites and find an extended kin group centred around a single maternal lineage, with unrelated (presumably inward migrating) burials being predominantly male. Such a matrilocal pattern is undescribed in European prehistory, but when we compare mitochondrial haplotype variation among European archaeological sites spanning six millennia, British Iron Age cemeteries stand out as having marked reductions in diversity'
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