Some executioner caspases also have non-apoptotic functions. This study shows that sublethal executioner #caspase activation enhances #hepatocyte proliferation via JAK/STAT3 signaling, revealing a role for executioner caspases in promoting liver #regeneration @PLOSBiology https://plos.io/3JEsH57

Caspases have well known roles in #apoptosis, but roles in other cellular processes are emerging... This study shows that #caspase -3 & -7 promote cytoprotective #autophagy in response to non-lethal stress by modulating PARP1 activity in #BreastCancer cells #plosbiology https://plos.io/41xfLVm

An intracellular #LiquidCondensate formed in plants by #LipidTransferase SFH8 associates with membranes; SFH8 cleavage by #Caspase-like protease ESP turns it into a solid filament that can modulate root development @Panosmoschou @Chenliu06 &co #PLOSBiology https://plos.io/3sZkIY0

ER stress induces #caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with #herpes simplex #virus type 2

#HSV type 2 infection promotes #neuronal #celldeath and #inflammatory responses via #ERstress-dependent #gasdermin E activation.

Søren Paludan and colleagues

https://www.embopress.org/doi/full/10.15252/embj.2022113118

Characterization of #Gasdermin E-mediated #pyroptosis in the basal chordate #amphioxus reveals that #GSDME is transcriptionally regulated by IRF1/8, involved in bacteria-induced tissue damage, and inhibited by #caspase inhibitor #PLOSBiology https://plos.io/3p6klcm

Characterization of #Gasdermin E-mediated #pyroptosis in the basal chordate #amphioxus reveals that #GSDME is transcriptionally regulated by IRF1/8, involved in bacteria-induced tissue damage, and inhibited by #caspase inhibitor #PLOSBiology https://plos.io/3p6klcm

Characterization of #Gasdermin E-mediated #pyroptosis in the basal chordate #amphioxus reveals that #GSDME is transcriptionally regulated by IRF1/8, involved in bacteria-induced tissue damage, and inhibited by #caspase inhibitor #PLOSBiology https://plos.io/3p6klcm

Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases
https://www.sciencedirect.com/science/article/pii/S1097276522002192

#pathogen #caspase #signaling #bacteria #t3ss

The findings of this study open up possibilities for further research on the role of ATP in apoptosis, as well as potential therapeutic targets for controlling cell death.

#ATP #Cell #CellDeath #Apoptosis #Caspase-3 #Pannexin-1 #Metabolism #FRET #Biosensors