The intricate mechanisms of #epigenetic silencing.

#PRC2 #Arabidopsis #VIN3 #VRN5

https://phys.org/news/2023-10-intricate-mechanisms-epigenetic-silencing.html

Development of a potent EED-targeted #PRC2 degrader, UNC7700, highly effective after 24 h in a diffuse large B-cell lymphoma DB cell line:

PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components https://pubs.acs.org/doi/10.1021/acschembio.2c00804

#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473

#Review on #Polycomb #PRC2 and growth disorder: Imagawa–Matsumoto syndrome: SUZ12–related overgrowth disorder. https://doi.org/10.1111/cge.14296