Lmst

Cientistas produzem enzima que “desmonta” proteção de bactéria resistente
- cijnusp
https://jornal.usp.br/ciencias/cientistas-produzem-enzima-que-desmonta-protecao-de-bacteria-resistente/
#Cincias #CinciasBiolgicas #Bactriaresistente #Biofilme #Enzimas #Infecohospitalar #Staphylococcusaureus

Staphylococcus aureus causes abscesses, pneumonia, and toxic shock via powerful virulence factors. #StaphylococcusAureus #MRSA #TSS #FoodPoisoning #GramPositive #CoagulasePositive #Microbiology #Pathology #USMLE #MedicalEducation

https://mymedschool.org/portfolio/u01-03-021-staphylococcus-aureus/?utm_source=mastodon&utm_medium=jetpack_social

Learn key exotoxin-producing bacteria and their mechanisms of disease. #Exotoxins #BacterialToxins #Microbiology #CorynebacteriumDiphtheriae #ClostridiumTetani #ClostridiumBotulinum #VibrioCholerae #BacillusAnthracis #StaphylococcusAureus #StreptococcusPyogenes #EColi #Pathogenesis #USMLE #MedicalEd

https://mymedschool.org/portfolio/u01-03-017-bacteria-with-exotoxins/?utm_source=mastodon&utm_medium=jetpack_social

Learn key biofilm-producing bacteria and their role in chronic and device-related infections. #Biofilm #BiofilmProducingBacteria #Microbiology #StaphylococcusEpidermidis #StaphylococcusAureus #PseudomonasAeruginosa #ViridansStreptococci #EColi #USMLE #MedicalEducation #Pathogenesis #AntibioticResist

https://mymedschool.org/portfolio/u01-03-011-biofilm-producing-bacteria/?utm_source=mastodon&utm_medium=jetpack_social

Learn the characteristic pigments of key bacteria for quick identification in microbiology. #PigmentProducingBacteria #Microbiology #StaphylococcusAureus #PseudomonasAeruginosa #SerratiaMarcescens #ActinomycesIsraelii #USMLE #MedicalEducation #BacterialIdentification #ClinicalMicrobiology

https://mymedschool.org/portfolio/u01-03-009-pigment-producing-bacteria/?utm_source=mastodon&utm_medium=jetpack_social

Two-dose treatment for staph bloodstream infections

September 16, 2025 At a Glance Two doses of the antibiotic dalbavancin produced results similar to standard 4-…
#NewsBeep #News #Headlines #antibiotic #bacteremia #dalbavancin #Dalvance #JAMA #JournaloftheAmericanMedicalAssociation #Latvia #LV #NicolasA.Turner #staph #Staphylococcusaureus #ThomasHolland
https://www.newsbeep.com/126641/

'Trends in the minimum inhibitory concentrations for four agents against methicillin-resistant Staphylococcus aureus in bloodstream infections in China: a 6-year multi-center study from 2017 to 2022' - an article published in “Decoding Infection and Transmission” on #ScienceOpen:

➡️ https://www.scienceopen.com/document?vid=532658bd-d61b-495d-a817-1c9ce5ffae95

#StaphylococcusAureus #MRSA #InfectiousDiseases #AntimicrobialResistance #Microbiology

Overcoming Antibiotic Resistance to Tetracycline in Staphylococcus aureus by Gold and Silver Nanoparticles - #antibioticresistance #Staphylococcusaureus #tetracycline #biofilm #Rplasmids #Staphylococcus #goldnanoparticles #silvernanoparticles #nanoparticles #AuNPs #AgNPs #tetKgene #tetMgene - https://link.springer.com/article/10.3103/S0095452724060021

Source: EBio Medicine, https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00460-2/fulltext

Summary
Background
To date, global priorities for new vaccine R&D have not been systematically identified for endemic pathogens. As part of Immunisation Agenda 2030 (IA2030), we have systematically identified priority endemic pathogens for new vaccine R&D based on country and regional stakeholder values to address this need.

Methods
MCDA surveys targeting policy makers and immunisation stakeholders in each World Health Organization (WHO) region were used to weight eight criteria for prioritisation. Applying those weights to regional pathogen data yielded regional top ten pathogen lists, which are intended to inform regional deliberations on R&D priorities. The regional top ten lists were combined into an IA2030 global priority list. To inform R&D, use cases for new vaccines and monoclonal antibodies were identified, then categorized in terms of the activities needed to accelerate progress.

Findings
In five out of six WHO regions, Annual deaths in children under five and Contribution to antimicrobial resistance were the most heavily weighted criteria. How participants weighted the criteria was not associated with their region, biographical characteristics, or areas of expertise. Five pathogens were common priorities across all regions: M tuberculosis, HIV-1, K pneumoniae, S aureus, and Extra-intestinal pathogenic E coli. Six pathogens were priorities in single regions. Combining regional top ten lists provided a global list of 17 priority pathogens for new vaccine R&D. Thirty-four distinct use cases were identified for new products targeting these pathogens. While most are in the “Advance product development” category, ten are in the “Research” category and seven are in the “Prepare to implement” category.

Interpretation
These priorities for new vaccine R&D will help stakeholders better respond to regional and country needs. The use cases will inform R&D and enable monitoring of R&D under IA2030.

____

https://etidioh.wordpress.com/2024/11/05/identifying-who-global-priority-endemic-pathogens-for-vaccine-research-and-development-rd-using-multi-criteria-decision-analysis-mcda-an-objective-of-the-immunization-agenda-2030/

#abstract #bacteria #eColi #health #HIVAIDS #infectiousDiseases #klebsiellaPneumoniae #mycobacteriumTuberculosis #news #research #science #staphylococcusAureus #vaccines #WHO

Antibiotic Zevtera (Ceftobiprole medocaril) approved by FDA for treatment of CABP, ABSSSI and SAB
The broad-spectrum fifth-generation cephalosporin antibiotic, Zevtera (Ceftobiprole medocaril sodium Inj.)...........
#ABSSSI #Antibiotic #BroadSpectrum #CABP #Ceftobiprolemedocaril #cephalosporin #FDA #pneumonia #SAB #Staphylococcusaureus #Zevtera
SCIE

https://www.scientificeuropean.co.uk/medicine/antibiotic-zevtera-ceftobiprole-medocaril-approved-by-fda-for-treatment-of-cabp-absssi-and-sab/

Transcriptional profiling of phagocytic leukocytes and microglia reveals a critical role for reactive oxygen species in biofilm containment during Staphylococcus aureus craniotomy infection. https://doi.org/10.4049/jimmunol.2200503 #StaphylococcusAureus #Biofilm #CraniotomyInfection #Microglia #Neutrophils

Bacteria on skin
Cause eczema's rapid growth
An unsettling sight

#staphylococcusaureus #eczema #atopicdermatitis #haiku #poetry

http://www.medicalnewstoday.com/articles/how-bacteria-can-colonize-skin-and-accelerate-eczema-growth

Molecular surveillance of daptomycin DAP-resistant #StaphylococcusAureus showed

🔵DAP-Resistance-Acquisition was linked to antiseptic rather than systemic antibiotic wound-treatment

🔵Resistance developed in all affected patients individually

Full Paper published in "Clinical Microbiology and Infection"
➡️https://authors.elsevier.com/a/1hNEB,RGPgSBN7

Hand mit Schutzhandschuh hält eine Petrischale mit rotem Nährmedium und Bakterienkolonien, darauf ein Wirkstoffplättchen. Ein Hemmhof ist nicht sichtbar. Im Hintergrund sind ein Mikrokop und Petrischalen-Stabel zu sehen.

#NewPaper -- we use #ExperimentalEvolution to show:
-- gaining a tetracycline efflux pump by HGT is v costly for Staph aureus in low O2 environments
-- treatment with tetracyclines prevents evolutionary adaptation to low O2 (otherwise by gyrB mutation)

Trade-off may explain why tetracyclines remain useful treatments for S. aureus because these infection sites are often characterised by #hypoxia

Led by amazing PhD Rebecca Hull

#Staphylococcusaureus #AMR #antibiotics

https://journals.asm.org/doi/10.1128/aac.00926-22