Lmst

[13/03/2025] SMArt Home - webinar Michała Stankiewicza

https://play.kontrabanda.net/w/fjm1iLbAzuRjQpH8KJhfm7

Research Assistant
Keele University

We are recruiting a Research Assistant to work on an exciting project aimed at defining the role of brown adipose tissue in spinal muscular atrophy.

See the full job description on jobRxiv: https://jobrxiv.org/job/keele-university-27778-research-assistant/

#brownadiposetissue #molecularbiology #mousemodels #Neuromusculardiseases #primarycellculture #spinalmuscularatrophy #Sc...
https://jobrxiv.org/job/keele-university-27778-research-assistant/?fsp_sid=3917

@thetransmitter

That's a massive big deal! Pins motor neuron degeneration on the lack of excitation supplied by its presynaptic interneurons rather than a problem intrinsic to the motor neurons themselves.

This is very much in agreement with findings in the fruit fly over a decade ago, where a key issue in a fly model for SMA (spinal muscular atrophy) is not in the motor neurons themselves but in the interneurons that synapse onto them and in the proprioceptive neurons that supply excitatory feedbacks.

"SMN Is Required for Sensory-Motor Circuit Function in Drosophila", Imlach et al. (McCabe lab) 2012.
http://dx.doi.org/10.1016/j.cell.2012.09.011

#neuroscience #SMA #SpinalMuscularAtrophy #Drosophila

Research Assistant
Keele University

We are recruiting a Research Assistant to work on an exciting project aimed at defining the role of brown adipose tissue in spinal muscular atrophy.

See the full job description on jobRxiv: https://jobrxiv.org/job/keele-university-27778-research-assistant/

#brownadiposetissue #molecularbiology #mousemodels #Neuromusculardiseases #primarycellculture #spinalmuscularatrophy #Sc...
https://jobrxiv.org/job/keele-university-27778-research-assistant/?fsp_sid=3469

The main causes of spinal misalignment #backpain #spinalmobility #spinalmuscularatrophy #spine

𝗔𝘂𝗴𝘂𝘀𝘁 𝗶𝘀 𝗦𝗽𝗶𝗻𝗮𝗹 𝗠𝘂𝘀𝗰𝘂𝗹𝗮𝗿 𝗔𝘁𝗿𝗼𝗽𝗵𝘆 (𝗦𝗠𝗔) 𝗔𝘄𝗮𝗿𝗲𝗻𝗲𝘀𝘀 𝗠𝗼𝗻𝘁𝗵, dedicated to raising support and knowledge about this rare hereditary neurological disorder. SMA causes the gradual loss of motor neurons in the spinal cord, leading to muscle weakness, difficulty with voluntary movements, swallowing, breathing, and scoliosis. It is a leading genetic cause of infant mortality but can also affect older children and adults in milder forms. Early diagnosis and a combination of treatments—including medication, physical therapy, and supportive care—can help improve quality of life. This month, let’s unite to educate, fund research, support families, and bring hope for a future cure.

#SMAAwarenessMonth #SpinalMuscularAtrophy #RareDiseaseAwareness #MotorNeuronDisease #MuscleWeakness #EarlyDiagnosis #SupportSMAFamilies #GeneticDisorders #ResearchForACure #PhysicalTherapy #HealthcareSupport #SCABPharmacy

Elucidation of the Gene Regulatory Network Related to Spinal Muscular Atrophy - #spinalmuscularatrophy #transcriptionfactors #machinelearning #p53signaling #transcription - https://link.springer.com/article/10.3103/S0095452724060033

India's Risdiplam launch dramatically cuts Spinal Muscular Atrophy (SMA) medicine cost to ₹15K. Learn how this affordable treatment offers new hope for patients.
https://www.mrmed.in/health-library/neurology/risdiplam-india-launch

#Risdiplam #SMA #IndiaHealth #AffordableMedicine #RareDisease #SpinalMuscularAtrophy #HealthNews #NatcoPharma #IndianPharma

Mackenzie’s Mission: With special guest:

*

Jonny Casella
… in conversation with Bill Kable

Before we hear from Jonny about the ground breaking medical mission inspired by little Mackenzie Casella we need to find out about Jonny and Rachael’s journey.

Fortunately not many of us face the tragedy and trauma that Jonny did after deciding to become a father. And having been… http://www.dadsontheair.com.au/shows/mackenzies-mission-2.html?utm_source=dlvr.it&utm_medium=mastodon #MackenziesMission #SMA #SpinalMuscularAtrophy #GeneticResearch #ParentingJourney

N.S. teen with spinal muscular atrophy applauds newborn screening at IWK
Van Bernard, 17, says when he was born, little was known or could be done about his diagnosis. His mother says screening could help other families avoid the anxiety they felt.
#globalnews #Health #IWKHealthCentre #SpinalMuscularAtrophy #VanBernard
https://globalnews.ca/news/10709328/spinal-muscular-atrophy-screening-iwk-van-bernard/

Today is August 1st – and it's also #WorldRNADay! 🧬💉 Discover how a tiny #RNA molecule can treat #SpinalMuscularAtrophy, a hereditary disease in children, in the new interactive explanatory video #flashMOOC #unibern: https://sohub.io/top1.

Transcriptome- and proteome-wide effects of a circular RNA encompassing four early exons of the spinal muscular atrophy genes. https://doi.org/10.1038/s41598-024-60593-7 #SpinalMuscularAtrophy,Sma #SurvivalMotorNeuron,Smn #CircularRna,Circrna #Proteome #Transcriptome

#SpinalMuscularAtrophy #sma I want no pity, but understanding. I mention my disability in my pinned introductory post. Outside of family, friends, & other disabled folk, I don't think I talk about it that much. For anybody curious, Spinal Muscular Atrophy type II is a genetic disorder that affects the signals to your muscles and motor skills. This leads to progressive muscle waste and a slew of other issues. I often compare my condition to the lottery when informing people about it. /1