Molecular Glue of the Brain: Cell Adhesion Molecules and Synaptic Stability
#Neuroscience #BrainScience #Synapses #NeuronalCircuits #Neuroplasticity #ExcitatoryInhibitoryBalance #DendriticSpines #ExtracellularMatrix #Interneurons #CognitiveHealth #Neurobiology #BrainDevelopment #NeuralConnections #Neuropsychiatry #BrainFunction
Ascl1 modified at 6 sites to be phosphorylation-resistant leads to in vivo reprogramming of Astrocytes into PV+ fast-spiking neurons. (Also this is enhanced by co-expressing Bcl2).
Reprogramming astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons by phospho-site–deficient Ascl1
Marichal et al., Science Advances 2024
https://doi.org/10.1126/sciadv.adl5935
Psychedelic drug DOI activates specific brain neurons to ease anxiety https://www.psypost.org/psychedelic-drug-doi-activates-specific-brain-neurons-to-ease-anxiety/?utm_source=dlvr.it&utm_medium=mastodon #PsychedelicDrug #DOI #BrainNeurons #EaseAnxiety #Interneurons
How do single #interneurons affect synchrony in vivo? @marco_bocchio &co show that CA1 #hippocampus interneurons form a functionally connected network that promotes synchrony between #PyramidalCells at the single neuron level #PLOSBiology https://plos.io/4f4tdDI
Inhibitory circuits in the #OlfactoryBulb shape info on its way from peripheral receptors to the cortex downstream. @NNUrban &co show that fast-spiking #interneurons perisomatically inhibit projection #neurons in the OB via synaptic detonation #PLOSBiology https://plos.io/4cFxDiV
Id2 GABAergic #interneurons comprise a neglected fourth major group of cortical inhibitory cells. #Neuroscience https://elifesciences.org/articles/85893?utm_source=mastodon&utm_medium=social&utm_campaign=organic
"We discuss preclinical evidence related to both neuronal & nonneuronal mechanisms that may be involved, touching upon the relevance of #interneurons, neuropeptides, & specific synaptic mechanisms in translating gamma stimulation into widespread neuronal activity within the brain. We also explore the roles of #microglia, #astrocytes, & the vasculature in mediating the beneficial effects of gamma stimulation on #brain function. Lastly, we examine upcoming clinical trials"
thinking about making a set of dlx creOFF AAV constructs a la @JDimidschstein and @sohallab. before i do - has anyone got a stash? initially gfp / chr2 but also likely switch gfp/dtomato too. for some 'NOT x' experiments. would be nice if they already existed! #neuroscience #neuromethods #aav #mouse #interneurons HT @elduvelle for the hashtags!
@DrYohanJohn this is a great reference work I use in class! Does anyone out there have something more recent? That is, are there important revisions to this story that I should be teaching?
Also, should we not just cave and call them #inhibitory cells rather than #interneurons, given the importance of #gaba ergic projection neurons? (Not trolling the developmental people who see gaba excitation).
https://academic.oup.com/pnasnexus/article/2/4/pgad065/7103449
"here we report that mice in which α5-GABAARs have been eliminated from pyramidal #neurons (α5-pyr-KO) continue to form strong spatial engrams and that they remain as sensitive as their pseudo-wild-type (p-WT) littermates to etomidate-induced suppression of place cells and spatial engrams. By contrast, mice with selective knockout in #interneurons (α5-i-KO) no longer exhibit etomidate-induced suppression of place cells."
Tweaks to autism-linked pathway tilt circuits’ signaling balance
https://www.spectrumnews.org/news/tweaks-to-autism-linked-pathway-tilt-circuits-signaling-balance/
#inhibitorysignaling #tuberoussclerosis #neuralcircuits #interneurons #circuits #synapses #autism #News #TSC2
Multi-omics study captures CNTNAP2’s far-ranging effects
https://www.spectrumnews.org/news/multi-omics-study-captures-cntnap2s-far-ranging-effects/
#single-cellsequencing #excitatorysignaling #neurotransmitters #prefrontalcortex #synapticvesicles #geneexpression #animalmodels #genenetworks #interneurons #mitochondria #mousemodels #glialcells #treatments #diagnosis #organoids #CNTNAP2 #autism #axons #News
One-rosette technique grows well-organized organoids
https://www.spectrumnews.org/news/toolbox/one-rosette-technique-grows-well-organized-organoids/
#inhibitorysignaling #geneexpression #interneurons #microglia #organoids #striatum #Toolbox #autism #SHANK3
Next, https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.15866
Here authors go deep into slice #ephys to show cholinergic neuromodulation of #LC NAergic cells and periLC #interneurons, via muscarinic Ach receptors.
In an interesting twist, mAchR activation *both* increases spontaneous activity of the forementioned cell types, *and* suppresses inhibitory input to LC-NA neurons.
Data indicate that, in a receptor-specific manner, cholinergic neuromodulation alters E/I relations within the LC
I'm sadly not at #SfN22 this year, but check out the fantastic
@candelabellot
tomorrow! Come along to the #Prefrontal #Interneurons symposium tomorrow to hear about her work on vH- PFC communication! Find it in Meeting room 6DE at 2pm
Of mice and human interneurons: A Q&A with Moritz Helmstaedter
https://www.spectrumnews.org/opinion/q-and-a/of-mice-and-human-interneurons-a-qa-with-moritz-helmstaedter/
#inhibitorysignaling #signalingimbalance #neuralcircuits #interneurons #mousemodels #monkeys #autism #cortex #QA
Gene therapy targets interneurons to tackle Dravet syndrome
https://www.spectrumnews.org/news/gene-therapy-targets-interneurons-to-tackle-dravet-syndrome/
#interneurons #genetherapy #mousemodels #seizures #monkeys #autism #News #GABA
Mini biopsies point to source of lethal seizures in model mice
https://www.spectrumnews.org/news/mini-biopsies-point-to-source-of-lethal-seizures-in-model-mice/
#interneurons #ionchannels #mousemodels #seizures #synapses #autism #News
Two groups of neurons govern autism-like traits in model mice
https://www.spectrumnews.org/news/two-groups-of-neurons-govern-autism-like-traits-in-model-mice/
#repetitivebehavior #geneexpression #neuralcircuits #socialdeficits #interneurons #mousemodels #striatum #autism #cancer #cortex #News
