Stanford researchers have developed "Evo", a genomic language model trained on bacterial genomes. Unlike AlphaFold which predicts structure, Evo works at the DNA level, learning from gene clusters.
It has successfully generated functional novel proteins (CRISPR inhibitors, antitoxins) with <25% similarity to known sequences.
Generative AI is now effectively simulating evolution at the nucleic acid level.
https://arstechnica.com/science/2025/11/generative-ai-meets-the-genome/