We did see 'health'-associated taxa increase in abundance post-therapy. There seemed to be a persistent difference in diversity between control group and PID group. We also observed interesting correlations with blood absolute #neutrophil counts and certain oral bacteria. This is certainly worth exploring further as these bacteria are part of the 'hedgehog' consortia in the dental plaque - dynamics are relevant for oral health in general. /end

Happy to see this out! We analysed the dental #microbiome of children with #primaryimmune deficiencies underwent non-surgical therapy. Prevalence of gum disease was higher in this group and the aim was to look at longitudinal data to see if therapy modulated the microbiome. 1/

https://onlinelibrary.wiley.com/doi/10.1111/jcpe.14201

We did see 'health'-associated taxa increase in abundance post-therapy. There seemed to be a persistent difference in diversity between control group and PID group. We also observed interesting correlations with blood absolute #neutrophil counts and certain oral bacteria. This is certainly worth exploring further as these bacteria are part of the 'hedgehog' consortia in the dental plaque - dynamics are relevant for oral health in general. /end

Happy to see this out! We analysed the dental #microbiome of children with #primaryimmune deficiencies underwent non-surgical therapy. Prevalence of gum disease was higher in this group and the aim was to look at longitudinal data to see if therapy modulated the microbiome. 1/

https://onlinelibrary.wiley.com/doi/10.1111/jcpe.14201

Smart! Stable isotope tracing via LC/MS metabolomics to discover unknown metabolic reactions in cells & mice. 🧪

#teammassspec #metabolomics

https://www.nature.com/articles/s41467-025-60258-7

... A. Oveta Fuller (1955-2022). Her obituary in The Lancet honors her "extensive contribution to the fight against the myths relating to HIV and COVID-19"

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00019-1/fulltext

On Wikipedia: https://en.wikipedia.org/wiki/A._Oveta_Fuller

3/3

#BlackHistoryMonth

....Jane Hinton (1919-2003).

She's the Hinton behind the Mueller-Hinton agar culture medium...

2/3

https://en.wikipedia.org/wiki/Jane_Hinton

#BlackHistoryMonth

In the mood to honor accomplishments in microbiology? A trio of African-American women who made a mark, with Wikipedia pages to visit:

Ruth Ella Moore (1903-1994). In 1933, she was the 1st African-American woman to gain a PhD in natural science

https://en.wikipedia.org/wiki/Ruth_Ella_Moore

#BlackHistoryMonth

Have you ever been annoyed when heating your oven that it does not tell you when it is hot? there is the little red light of course but who wants to keep going to the kitchen checking that all the time!

With my very rudimentary skills I built a little device from an Arduino that monitors the oven light and sounds a buzzer when the oven is at temperature (i.e. the light turns off). More details and code etc. on my blog: https://rhizobia.nz/node/65 #Arduino

Do I know anyone who has recently (past few years) secured a New Investigator #BBSRC Research grant? We are writing one and could really do with an example of what works..
If you do and would be willing to share all or part of the application material the #NeuroESC lab would be eternally grateful 🙏

Edit: this is what we're applying to: https://www.ukri.org/opportunity/bbsrc-new-investigator-award-2025-round-one-responsive-mode/

Edit 2: Thanks to you all we've already got 3 example applications! You are all awesome 🤗 This will already help a lot, the last thing we would need is one from the most recent call (Jan 2024?) and as a "New Investigator", especially if you are also willing to share the reviewers' comments which are really useful to see what people look for in these applications - DM me if so 🙏
(It's our first one... lots to learn but not so many opportunities for learning!)
#Research #ResearchFunding #ResearchGrants

🎓 PhD Opportunity with me! 🚀

📢 Calling for aspiring bioengineers to join us!

Develop organotypic models to explore host-microbe dynamics due to metabolic signals. Work with tissue systems, biofilms, imaging, and mass spectrometry.

💡Get in touch, and apply here: https://www.cpm.qmul.ac.uk/cdt/applications/

#phd #organoids #bioeng #metabolomics #microbiology

🎓 PhD Opportunity with me! 🚀

📢 Calling for aspiring bioengineers to join us!

Develop organotypic models to explore host-microbe dynamics due to metabolic signals. Work with tissue systems, biofilms, imaging, and mass spectrometry.

💡Get in touch, and apply here: https://www.cpm.qmul.ac.uk/cdt/applications/

#phd #organoids #bioeng #metabolomics #microbiology

Dr. Rebecca Lancefield (1895 – 1981) studied streptococcal bacteria. Her research laid the foundations for understanding how diseases like strep throat. She was the first woman to became president of the American Association of Immunologists. To honour her significant contributions to bacteriology, DSMZ researchers named the strain Streptomyces lancefieldiae (DSM 40712) after her.

#herstory #HonoringWomenInSTEM #WomenInScience #actinomycetes #microbiology

Today was a special day. #nanopore #LongReadSequencing

I'm running some tests comparing ANI-mash-dash distances (though using -M for the last, which might defeat the purpose of its inclusion?) across similar microbial genomes.

What are people settling on as a good kmer choice for decent strain level genome distance resolution these days?

#bioinformatics #microbiology

Inferring metabolism without performing metabolomics. 🙃 Interesting study combining long-read sequencing for MAG recovery with short-read RNAseq to get at different microbial roles in carbon flow in anaerobic digesters. #Metagenomics #CarbonCycle #Microbiome

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-024-01830-z

I have a big microbial sequencing batch coming up that will require decent methylation calling.

How's ONT vs PacBio on this front? R10's direct methylation detection is exactly what I'm looking for, but curious about first-hand experience from researchers for both platforms.

#sequencing #bioinformatics #nanopore #pacbio

'Musk then brought in two of his cousins, James and Andrew Musk, to oversee engineering teams. Software engineers were told their code would be reviewed, unusually, on paper. Privacy officers panicked as thousands of sheets, filled with the company’s intellectual property and its users’ personal data, were printed out and carried around the building. Shredders were hastily bought and the engineers had to line up, watched by security guards, to destroy the pages.'

https://www.newstatesman.com/culture/books/2024/09/how-elon-musk-killed-twitter

Insightful #perspective by Papenfort and @storzlab on how small regulatory #RNAs (sRNAs) in bacteria reveal protein functions and metabolic pathways. @NIH @UniJena #RNAResearch #Microbiology https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00304-0?utm_source=dlvr.it&utm_medium=mastodon