Paul Macklin

multicellular systems & cancer with #PhysiCell#COVID19 & immune modeling • #DigitalTwins#OpenSource#astrophotography • Associate Professor of Intelligent Systems Engineering at IU Bloomington

(@MathCancer on Twitter) Also: @mathcancer

#fedi22 #compbio #mathonco #mathbio #ABM #agentbasedmodels #HoosierMast

Paul Macklin boosted:
Meredith WhittakerMer__edith@mastodon.world
2023-01-09

How it started how it's going

Screenshot of my toot, which says: "AI will not replace you. A person making half what you do with no benefits whose job is the same as yours but now includes babysitting AI will"A tweet that says: "A client informed me that he will no longer pay me to write content for his website because AI can write it for free but he wants to pay me a fraction of my usual rate to "rewrite it" in different words so it can pass Google's AI detection screening."
2023-01-09

@fertiglab congrats Elana!!

Paul Macklin boosted:
2023-01-09

RT @jmuiuc@twitter.com

Excited to share our paper in @NatureGenet@twitter.com: SPICEMIX, a joint model of spatial info and gene exp from spatial transcriptome data. Advances upon NMF w/ integration of graphical model, resulting in more meaningful latent reps of cells and spatial metagenes. nature.com/articles/s41588-022

🐦🔗: twitter.com/jmuiuc/status/1612

Paul Macklin boosted:
2023-01-09

Super crepuscular rays through the clouds at sunset in London this evening

Paul Macklin boosted:
Mary McIntyre AstronomyMaryMcIntyreAstro@astrodon.social
2023-01-09

Here's an animation of #Comet C/2022 E3 (ZTF) from 27th Dec '22. 1 min single exposures showing its movement between 02:36 - 04:24 UT. 8" #RitchieChretien telescope + Altair Hypercam 183C camera. Collab with my husband @markmac99 #C2022E3 #CometImaging

2023-01-09

@ryderdavid thanks!

Yes I'll admit I also view it more as the enemy, but gosh it's pretty!

2023-01-08

99.7% illuminated #moon, captured as a 2-panel mosaic from my backyard on January 7, 2023.

I tried to keep a delicate touch in processing, in particular to avoid oversaturation and overbrightening that tends to wash out details. #astrodon #astrophotography

Tech details: astrobin.com/3sj03t/

Prints available at: mathcancer.darkroom.com/produc

99.7% illuminated moon - 2-panel mosaic
2023-01-05

Just finished processing #Comet #C2022E3 ZTH.

This shows 2 hours of travel against the background stars, captured from my Indiana backyard at 4 am this morning.

Note the separate dust and ion tails.

#astrodon #astrophotography #HoosierMast

tech details: astrobin.com/9a9i6o/

Comet C/2022 E3 ZTH on January 5, 2023, showing two hours of motion against the background stars. Note the separate dust and ion tails.
Paul Macklin boosted:
2023-01-04

Wanted to share our recent paper on how a cell, Chlamydomonas, "knows" when its flagella are removed. When flagella are detached in this unicellular alga, they grow back in an hour, and while that happens a whole program of genes are turned on. Here we show that induction depends on intraflagellar transport, suggesting a model in which a repressor is sequestered in flagella when they are re-growing, and then accumulates to turn genes off as growth tapers off.
molbiolcell.org/doi/10.1091/mb

2023-01-04

Our Corgi for #SpeakerOfTheHouse.

Tenacious. Pro-America. Anti-werewolf.

Corgi playing tug-of-war.
2023-01-02

OK, it's 2023. Is there any way to do auto-hyphenation in google docs yet?

Paul Macklin boosted:
2023-01-02

RT @AMathelier@twitter.com

Come work with us! @NCMMnews@twitter.com is seeking experienced and self-driven candidates for the role of Head of Research Strategy, Communication, and International Relations.
@UniOslo_MED@twitter.com @UniOslo@twitter.com

jobbnorge.no//en/available-job

🐦🔗: twitter.com/AMathelier/status/

Paul Macklin boosted:
Kevin Moerman 🔓🦿:julia:kevinmoerman@fosstodon.org
2022-12-30

The Journal of Open Source Software (JOSS) is looking for editors! If you are keen to help this exciting journal check this link and fill out the form:
blog.joss.theoj.org/2022/12/ca

Let me know if you have questions about the journal too.

joss.theoj.org

#opensource #diamond #openaccess #openscience

2022-12-30

@gepasi ah. Good luck!

2022-12-29

@gepasi And I'll trade a modest memory cost to avoid repeated calculation any day of the week. :-)

What you describe sounds like a simple summation over a list of indices.

something_for_i = sum_{j in N_i} data_j

That's a pretty cheap calculation once you pre-compute N_i. And this works for any mesh.

2022-12-29

@ptgm @gepasi @soliman

That's a nice structure. I once made similar codes for cellular automata that allowed arbitrary neighbor lists (or stencils).

Now in my off-lattice ABMs (PhysiCell), each cell tracks its list of interacting cells (dynamically). Incidentally, an array of memory addresses.

2022-12-29

@gepasi @soliman

Right. You only have to compute and store the topology once.

If you divorce the topology from the individual cells from the sites / topology, this never needs to be recomputed.

My position is in voxel i. My neighbors are N_i. I compute whatever I need to compute over N_i. Sometimes, I need information in A[i,j] (e.g., area of the interface) to make my computations.

Should be cheap to loop over these lists of arrays. Works for finite volume codes in n-D.

2022-12-29

@gepasi @soliman
Hmm, not sure what you mean in indices of sides of neighbors. I guess I don’t understand the types of calculations.

In general meshes (and this works in n dimensions), each voxel with index i can store a neighbor list N_i.

If you need to store some information A that varies on voxel i being a neighbor of voxel j, you could store this in an array A[i,j]. That makes for easy access for j in N_i

Constructing the arrays is a one-time cost (unless you have a moving mesh).

2022-12-28

A question for comet experts.

I've been reprocessing my C/2021-A1 Leonard photos, and I noticed that if I zoom in on parts of the histogram, I see a teardrop shape close the nucleus. Is this showing the edge of the magnetic cavity?

Shown with exaggerated curves (and then with more regular coloring), with a diagram from the ESA here for comparison:

esa.int/ESA_Multimedia/Images/

#astrodon #astronomy #astrophotography

Zoom on nucleus and coma of C/2021-A1 Leonard. (exaggerated processing)Comet C/2021-A1 Leonard (regular processing)
Paul Macklin boosted:
2022-12-28

Hi all! For any mathematical biologists who will be at the #JointMathMeetings in Boston, I will be co-chairing a special session on "Mathematical Modeling of Ecology and Evolution: From Infectious Disease to the Evolution of Cooperation", together with Daniel Cooney, Chadi Saad-Roy, and Olivia Chu. Talks will span a wide range of interests--hope to see some of you there!

jointmathematicsmeetings.org/m

#MathematicalBiology
#Epidemiology
#EvolutionaryGameTheory
#Ecology
#Evolution

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