DendroTweaks, an interactive approach for unravelling dendritic dynamics.

🔗 https://elifesciences.org/articles/103324/?utm_source=mastodon&utm_medium=social&utm_campaign=organic

⏰🧠 Nerve cells age differently
Researchers led by Professor Björn Schumacher have used the model organism C. elegans to prove for the first time that nerve cells age differently. Using an “aging clock” they developed themselves, they were able to precisely determine the biological age of individual neurons and
Using an AI-supported approach, they were able to identify potential protective substances.

Read more 🔗 https://uni.koeln/FKJ35

#uniköln #unicologne #AgingResearch #Cecad #HealthyAging

“When writing by hand, you’re forming all these intricate motor patterns, whereas when typing, it’s only very simple finger movements,” https://www.nature.com/articles/d41586-026-00320-6

RE: https://genomic.social/@jfy133/116001072029556812

#Zenodo addresses recent outages and slow loading times, noting a strong increase in usage and a suspected impact from automated and #AI driven access. They outline planned measures to stabilize and further improve the infrastructure 👍

Looking at #correlation plots, I sometimes see R² ("R-squared") reported instead of the Pearson correlation coefficient r. While R² = r² holds in simple linear regression, reporting R² alone can mislead by omitting directionality. I have summarized the key differences between r and R² and tried to give a best-practice guide on when to use each:

🌍 https://www.fabriziomusacchio.com/blog/2025-09-13-r_vs_r_squared/

#Python #Statistics #DataScience #Neuroscience

I have no idea why my #software works! #meme

Due to a recent discussion with colleagues on whether and when to use #LinearMixedModels (#LMM), I wrote a blog post comparing LMM to other approaches using simulated data. I thought, it may also be useful for others working with hierarchical data structures in #neuroscience and beyond.

🌍 https://www.fabriziomusacchio.com/blog/2026-01-31-linear_mixed_models/

#Python #Statistics #DataScience #MixedModels #Statsmodels #ANOVA #ANCOVA #GLMM #regression

More from Arthur C Clarke's book "2010" -

"Some of the sulphur lakes are hot enough to glow, but most of the light comes from electrical discharges. Every few minutes the whole landscape seems to explode, as if a giant photoflash has gone off above it. And that’s probably not a bad analogy; there are millions of amps flowing in the flux-tube linking Io and Jupiter, and every so often there’s a breakdown. Then you get the biggest lightning flash in the Solar System."

https://ia600800.us.archive.org/7/items/SpaceOdyssey_819/2010_Odyssey_Two_-_Arthur_C_Clarke.pdf
4/n

The Galilean moon Io is a world tormented by active lava-spewing volcanoes, as it is stretched and squeezed by the gravitational forces of Jupiter, and the moons Europa and Ganymede.

Is there a global shallow ocean of hot magma underneath the surface or are the volcanoes powered by their own chambers of magma?

A new study by the NADA Juno team, presented at AGU24, indicates the latter, as shown in the graphic below.

https://www.jpl.nasa.gov/news/nasas-juno-mission-uncovers-heart-of-jovian-moons-volcanic-rage/
https://rdcu.be/d3kUh
1/n

Thanks @albertcardona for sharing this! I wasn’t aware of the #BayeuxTapestry at all, nor that #Halley’s #Comet played such a prominent role in #MedievalArt and perception. A fascinating story! https://mathstodon.xyz/@albertcardona/115992114758518351

Eruzione senza precedenti rilevata su Io

#Io #Juno @astronomia

La missione Juno ha osservato una potentissima ed estesa eruzione vulcanica sul satellite più attivo di Giove. L’evento, registrato dallo strumento Jiram dell’Agenzia spaziale italiana, è il più energetico mai rilevato fuori dalla Terra ed ha coinvolto molteplici sorgenti vulcaniche attivate simultaneamente, rivelando l’esistenza di vasti sistemi magmatici interconnessi nel sottosuolo del satellite.

https://umbertogaetani.substack.com/p/eruzione-senza-precedenti-rilevata

This video was recently published by #ESA, but it was extremely dark, so it was hard to see details.
Thanks to the ESA media team who provided me with a higher quality version, I was able to recover lots of shadow details and correct the hotpixel noise.

Original: https://www.esa.int/ESA_Multimedia/Videos/2025/12/Nature_s_fireworks_from_space

Microglia adopt fundamentally different strategies for surveilling the health of neurons during chronic neurodegeneration.
https://elifesciences.org/reviewed-preprints/107650?utm_source=mastodon&utm_medium=social&utm_campaign=organic

A new study uncovers an anti-resonance effect in Wnt signalling, where pathway activity is suppressed at specific signal frequencies. Using optogenetics and modelling, the work shows how signal timing shapes cell fate decisions.

🔗 https://elifesciences.org/articles/107794?utm_source=mastodon&utm_medium=social&utm_campaign=organic

An important study maps how nerves control the Drosophila male reproductive tract, revealing two types of glutamatergic neurons that also release serotonin or octopamine.

🔗 https://elifesciences.org/articles/108225?utm_source=mastodon&utm_medium=social&utm_campaign=organic

#ArXiv is cracking down on #AI #slop and will only allow initial submissions based on recommendations from established ArXiv authors.

🌍 https://www.science.org/content/article/arxiv-preprint-server-clamps-down-ai-slop

#preprint #AIslop

Message to all past #SNUFA presenters (talks and posters). I've redesigned the website and there's now an option to add links to related papers and embed a video of your talk. Go to your abstract page and follow the instructions. Here's an example of what it looks like:

https://snufa.net/2025/abstracts/abdelqader-alkilany-neuromodulation.html

#MachineLearning anlysis of 20 years of in situ measurements in the #Earth's #magnetosphere brings new insights on #MagneticReconnection processes:

📄 https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2025GL119118

#SpacePhysics #Plasma #PlasmaPhysics #SolarWind #Reconnection @irap https://social.numerique.gouv.fr/@irap/115966776951772619

New protocol from SWC reduces off-target effects in optogenetics 🚥

Light can unintentionally activate retinal cells, complicating results. The protocol minimises light leakage and verifies off-target activity is reduced.

➡️Read the paper in STAR Protocols: https://star-protocols.cell.com/protocols/4708

➡️For full details of the method and its use, check out the paper in iScience: https://www.cell.com/iscience/fulltext/S2589-0042(24)02377-0

Bitlocker is a Microsoft product that encrypts your laptop hard drive etc. Apparently, Microsoft exfiltrates a recovery key for your Bitlocker encryption and stores it in their cloud, they give it out to law enforcement at request. And of course, they give it out to whoever compromises their system and steals that info. Bitlocker is completely worthless trash. Do not rely on it for information security.

https://www.forbes.com/sites/thomasbrewster/2026/01/22/microsoft-gave-fbi-keys-to-unlock-bitlocker-encrypted-data/